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Under a new European Union (EU) research initiative called “Development-Smart Innovation through Research in Agriculture (DeSIRA),” the EU Delegation to Malawi has engaged with CGIAR Centers operating in Malawi to implement a multidisciplinary research action that seeks to identify, develop and test integrated technology options to address complex and diverse challenges affecting the agricultural and food systems in Malawi under an increasing threat of climate change. The CGIAR and partners will implement this action through its CGIAR ‘country collaboration’ mechanism, launched in Malawi in 2016. It will take advantage of the capacities of all eight CGIAR Centers present in Malawi, with contributions from European Institutions, to work together on a common and holistic research intervention in view to promote development and use of effective integrated technological options in response to the diverse and complex challenges affecting the agriculture sector.